Clothing business Essay Example | Topics and Well Written Essays - 3750 words

Clothing business - Essay Example The project also considers the stakeholders who serve the purpose of decision making processes. The difference between the anticipated and achieved growth for the company will not be excluded. The point of view of the customers and some of the managerial limitations will cover the topic of discussions. There will also be some recommendations in order to improve the performance of the company in the years to come. Introduction The organization selected for the project is J.C. Penny Company Inc. It is a chain of the mid range department stores in America. It is based in Texas. The company also operates in many small markets of the nation as catalog sales merchant. The company operates in all the states of the United States. The stores of the company are mainly located in the suburban shopping malls. When the trend of shopping malls came up in the 20th century, the company took the initiative to reallocate the stores there so that it could catch the eye of more people than in the suburb an areas. Currently, the company has opened some new sole stores; some of them are close to the competitors’ stores. Some of the newly developed stores can be regarded as the big-box stores. The company has streamlined the catalog as well as the distribution operations and is undergoing renovations at the store levels. The company also entered the playing field of internet marketing in the year 1998. Apart from the sale of usual merchandise, the stores of the company also offer several other departments like restaurants, studios and jeweler shops. The company was founded in the year 1913. In 1914, the headquarters of the company was shifted to New York City with the belief that it would simplify the transportation and usual operations of the organization. The first subsidiary of the company was named The Crescent Company. By 1928, the company was able to open its 1000th store. This signifies the potential of the company and how efficiently the company was being operated. In 2 007, the company launched its largest private brand in the history of the company. New additions were made in 2009 in the young men’s department which included the expansion of the private brand named Decree. The year also marked an agreement with a private coffee store which allowed them to open up cafes inside the stores. Goals of the company The sustainability report of the year 2009, announced some of the internal goals of the company which were directed towards reduction of facility energy consumption by around 20 percent per gross square foot. The efforts will be met by 2015 through the improvements in energy efficiency. The culture of the company is to advocate conservation practices. In the last decade, the company invested more than 130 million dollars with the aim to install advanced technology in metering and technologies towards high efficient heating. This type of initiatives from the part of the company resulted in saving of more than 80 million pounds of greenh ouse gases. The company also plans to obtain around 25% of their energy need from renewable sources. Measures relating to energy management as well as efficient strategies have been undertaken. Among the other goals of the company includes providing services to the customers at possible lowest cost, enhance the consumer satisfaction and build a healthy

Sky broadband Essay Example | Topics and Well Written Essays - 2500 words

Sky broadband - Essay Example In theory and practice, IMC strategies are aimed at combining or integrating the elements of the communication mix, such as advertising and public relations in order to create a balanced and consistent marketing communications message that strengthens the brand. IMC, if managed correctly gives an organization a competitive advantage because of its cost effectiveness and its ability to maximize the impact of its product and services development and the communication of the organization's messages within the marketplace (Ireland, 2002). There is no shared definition of integrated marketing communications in the scholarly literature, but the tenets of IMC have been adopted by businesses globally, and scholars do agree on the theoretical underpinnings of the IMC model (Kitchen, Schultz, Kim, Han, & Li, 2004). The literature offers some outlines for conceptual frameworks that can guide agencies and organisations to ensure an effective implementation of an integrated marketing communications program (Kitchen, Schultz, Kim, Han, & Li, 2004). According to Fitzpatrick (2005), "... According to Fitzpatrick (2005), "one of the defining features of IMC is that it uses all forms of communication and all sources of brand or company contacts as prospective message delivery channels. The ultimate goal is to influence buying behavior through directed persuasive communication targeted to a broad range of stakeholders that influence brand image and organizational reputation" (p.94). Scholars and practitioners of marketing communications believe that the increase in the number of communication channels, media fragmentation, segmentation of consumer preferences, sophistication of consumer databases and analysis, and importance of relationship building to strengthen brand image has forced institutions to consider and adopt a more sophisticated, strategic, and integrated marketing communications effort (Kitchen, Schultz, Kim, Han, & Li, 2004). Integrated marketing communications has evolved from a concept of bundling all of an institution's communications in order to speak with one voice, to a strategic management effort that utilizes detailed consumer information to develop relevant communication (Kim, Han, & Schultz, 2004). Kim, Han, and Schultz (2004) stress the need for organizations to speak to their consumers with an integrated approach because today's consumers are not dependent on organizations to provide them with information. Technology has helped to fragment the current media environment and to increase the speed of information gathering. The result is that consumers are able to integrate their product information consumption without the aid of the organization. In addition to message integration, effective IMC must be supported by marketing budgets and appropriate staffing, skills, and

Culture and Globalization Essay Example for Free

Culture and Globalization Essay INTRODUCTION Identity is a question that may be expressed by an anxiety and a hope at the same time. The anxiety lies in the sense of the existence of our Moroccan identity in all its dimensions, Arabo-berber, Muslim negro-African and modern. It also lies in our existence in the world in different parts of the planet where we have decided, voluntarily or not, to assert our existence; a planet that has become a finished space, a global village, surrounded by all kinds of flows, economic, human, electronic, and cultural, which are aspects of globalization; a globalization that could not only be a kind of interdependence among the national spaces which existence is still alive but also an internal phenomenon in these spaces. The advantages and disadvantages of this multiform process can diverge from one partisan to another. Some see in it the chance of a new world and others see in it the risk of an incomparable oppression. The problem of the Arabo Islamic identity or Arab identity occupies the front of the scene. The Islamic world has never been so active in the sense of the expression of identity, maybe because of the more and more enigmatic character of this identity because as Dryush Shayagan reminds, more than the ethnic and the religious identities, we find a third one in addition that emerges from modernity. He adds that the three identities fit one into the other, create more and more complex fields of interference, and exploit territories that remain most of the time incompatible with each other. He goes on declaring that today, these identical cultures are situated between the â€Å"not yet† and the â€Å"never ever†: not yet modern and never ever traditional. These identities that live henceforth, in â€Å"between the two† are totally burst according to Dryush.[1] At first glance, this triple identity raises obstacles to communication, but on the condition of succeeding in fitting out their respective spaces, it offers on the other hand, new possibilities of communication. The assertion of a reactive and massive Arabian Islamic identity was the adequate answer to the colonial dominion. Today, however, the reflection has to fit and adapt itself to the requirements of a situation namely, globalization, that orders that identity becomes seen as open, diverse and it has to be attentive to pluralism in the internal as well as the external places. We can think that the new network of information and communication will favour the emergence of new forms of citizenship susceptible to fill the current democratic deficit. Media permanently present information in the different parts of the world. With the means of information which the internet network prefigures today, the individual can have a more active role in the search for information. One can also contact a multitude of people of different nationalities, discuss problems of public interest, and express his/her opinions in public forums. GLOBALIZATION, CULTURE, AND THE MOROCCAN IDENTITY It is crucial to see globalization from an academic point of view as there is a strong link bounding globalization and culture. The global culture belongs to what Simon During calls â€Å"transnationalization.†[2] This latter is the process by which cultural products extend their actual space to emerge in a global area. Cultural studies are a kind of reaction to this process. Going deeper in this perspective, we come across many points that may link globalization to culture if we consider that culture is a local issue that may be influenced by the global market, the global sight, or may itself influence the global sphere if it is considered as a tradition or a way of life. Culture, from another view, maybe considered as the basis of the construction of one’s identity but once influences by globalization, the identity may change and we may adopt some practices and beliefs that may be no more appropriate to the local culture. Education is another point where globalization and culture meet. Students nowaydays, are no more interested by some issues tackling family or social events, but rather opt to get aware of the global economic and capitalistic changes that the actual world witnesses. Culture is a part of our identity. If we change culture, we change our identity. Stewart Hall argues that in a changing history, identity should remain the same though it is far from being the case of the modern world we’re living in and where identities are in a permanent process of change and transformation and this is the result of globalization. Always according to Hall, the construction of identity is made by the sight of the other. In other words, the negative view on the other makes of our identity a positive one. The process of constructing identity then is based on opposition. If the sight of the other makes of us who we really are, we are then no more free to chose according to our own tastes but rather chose according to others’ reactions[3]. This may seem ambiguous in a sense and annoying in another. How can globalization affect our own sense of belonging? Belonging to a particular nation and adopting a specific culture is not a matter of choice, it is because we belong to a certain ethnic group that has its own tradition, culture and religion. Once we find ourselves involved in a pre-created world, the acceptance becomes an automatic reaction, but when our sense of belonging to a cultural space or another becomes guided by the global pressures, our identity gets hurt and our mind fragmented and confused between what is ours and what is theirs (what is local and what is global). â€Å"The global popular† is the means of communication that occupies an important place in the projection of visual images to spread information (TV, satellite, internet†¦). If I insist on citing the global popular as one of the links between globalization and culture, it is because I judge it of a high importance and necessity to remind the idea that Simon During came with and which expresses the impossibility to separate the global popular from the global culture. He kept arguing that the reason was not only that both of them belong to a single globalizing system but also because the relation between various forms of cultural products are changing and transacting.[4] Similarly, Arjun Appadurai cited in his essay â€Å"Modernity at Large† one of the most important means of the circulating forms which is the â€Å"mediascape†. Like the global popular, mediascapes allow any information to become local through all kinds of the modern media. By this way the local culture may be adopted by different societies and consequently be global.[5] GLOBALIZATION AND MEDIA Today globalization arouses number of controversies. The term by itself condenses anxieties: it evokes, quite at the same time, the shrinkage of the planet bound to technological innovations and the massive impact of the triumphant capitalism that imposes its extreme dominance. Appadurai approaches, in a frontal way, the question of globalization. He put in the centre of his analysis the notion of flows. For him, what defines the contemporary world is much more circulation than structures and stable organizations. The proof is quite clear when we see people constantly moving from one place to another and the extraordinary development of mass communication with images transited throughout the planet. Until then, the individual lived and conceived himself in certain limits. From a simple geopolitical point of view, the nation state was considered as a stable referent: within it, the dimension of the local used to have a great importance conferring to each individual in a given society their privileged points of anchoring. In this context, the identical constructions occur in a permanent game of opposition between the self and the other, between the inside and the outside. But migrations on the one hand, and the media flows on the other hand, disrupted the spreading order until then. What interests Appadurai is the way this situation not only alters the material life of people but also tends to give an incomparable role to imagination. This does not mean that previously societies have not abundantly, neither in their mythological, literary nor artistic productions, appealed to this faculty. Henceforth, imagination is no more limited in some specific domains of expression, but it changes the daily practices, notably the migratory situations where migrants find themselves obliged to create in their exile a world of them by using all the images that media allow them to receive.[6] The technological progress: Internet The cable and internet offer multiple means to reconstitute communities including migrants and those who stayed in their countries. When we come across globalization of communication we inevitably think of internet. Internet is considered to be the symbol of and at the same time, a vehicle for the development of the future mediatic landscape. As a polymorphic tool spread everywhere, internet is actually inescapable in the study of the actual communication processes. If we consider internet as a media, we automatically notice that it is a quite particular one. Among modern mass media, internet is characterized by a potentially or at least virtually wide broadcasting. It is one of the facets of the internet ideology: everybody can have access to messages, everywhere and so to speak with no constraints, and at the same time, internet presents specific characteristics that make of it an exceptional media. Unlike press or radio-television that necessitate material and financial means, licenses, and a diffusion and distribution network, by internet everything is easier. Everybody can be a transmitter and everybody is potentially provider of contents but not everybody can create his/her own television station contrary to internet by which each one –or almost– can create a web site with only an online computer. All this is almost free more than the accommodating of private individuals that is also, more or less, free. If we consider internet as a media, it is then the time in the history of mass communication when each citizen and each association has the ability to play in the same ground as that of the wide mediatic groups or the big companies. Yve Thiran states that from this point of view, internet is a means of communication par excellence and it is not surprising that the excluded traditional media were the first to use it.[7] What seems to be new in the case of internet is not really the fact that it facilitates the emergence of multiple forms of sites and more or less alternative means of information, but rather the fact that the local structuralizations have voluntarily or not, reached the world as a whole. The neighbouring radio station’s diffusion is limited in the neighbourhood, while the expression on the Net may give the impression to address the whole planet. A neighbouring radio station, once installed in the web, can be heard by the whole world. Contrary to the press of radio-television, internet still looks for its place in the media landscape[8] grouping sites together, contents, services and very (too) diverse possibilities to aspire to a real unit of speech (but it is not probably the purpose of internet neither), in a social gratitude other than the connotations that can be socially planed on the new technologies of information and communication in general. In other words, as we find everything on internet, it is still its strict technical dimension that allows an observer to apprehend it, to seize it mentally and conceptually and to succeed in defining it differently. What is internet then? It is a media, a commercial space, a means of information, a shop window, and a place for exchange and expression; that is to say, so many activities where the interlocutors position themselves differently. The telephone is not a newspaper; nevertheless, internet can be at the same time a telephone and a newspaper, an advertisement hoarding and a room of debate. CONCLUSION Born Jamaican, the English cultural theorist Stuart Hall argued that identity must be understood in terms of politics of localization, of location and statement –not as a process of discovery of lost roots but as the construction of a new or emergent shape of ourselves, linked at the same time to the actual social relations and to the contemporary power relations–. While most of us clearly wish to respect most of the aspects of our tradition and history, Hall suggests that we also need, for speaking, to understand languages which we were not taught. We need to understand and revalue the traditions and inheritances of cultural expressions in a new and creative way as the context in which they are produced evolves constantly.[9] [1] Shayagan Dryush,  « La Lumià ¨re vient de l’Occident,  » Paris : l’Aube, 2001, Entretiens du XXI Sià ¨cle,  « Oà ¹ Vont les Valeurs,  » UNESCO, Abbin Michel, Paris, 2004. [2] Simon During,  « Postcolonialism and Globalization,  » Culture, Globalization and the World System, ed., Anthony King, Dinghamton, 1991. [3] Stuart Hall,  « Old and New Identities, Old and New Ethnicities,  » Culture, Globalization and the World System, Current Debates in Art History 3, State of New York: Bihghamton, 1991, pp. 41-68. [4] Arif Dirlik,  « The Local in the Global,  » Global/Local: Cultural Production and the Transnational Imaginary, eds., Rob Wilson and William Dissanayake, Durham: Duke UP, 1996. [5] Arjun Appadurai,  « Modernity at Large,  » Cultural Dimensions of Globalization, Public Worlds, Vol. 1, London: University of Minnesota Press, 1996. [6] Arjun Appadurai, Aprà ¨s le Colonialisme, Paris : Payot, 2001. [7] Yve Thiran, Sexes, Monsenges et Internet, Bruxelles : Castells-Labor, Coll.  « quartier Libre,  » 2000, p. 42. [8] Yve Thiran shows that the internet needs traditional media such as television to be able to claim the impact that it had notably during the Clinton-Lewinsky affaire. (Thiran, p. 43) [9] Stuart Hall,  « Old and New Identities, Old and New Ethnicities,  » Culture, Globalization and the World System, Current Debates in Art History 3, State of New York: Bihghamton, 1991, pp. 41-68.

Drug Discovery Process Of The Bio Pharmaceutical Industry Biology Essay

Drug Discovery Process Of The Bio Pharmaceutical Industry Biology Essay The development of new pharmaceutical products is a long, expensive and uncertain process. It takes an average of 10 to 15 years for a new drug to move from the discovery phase into the marketplace, and the average cost for the development of a new drug is approximately $800 million. Out of 6000 compounds initially screened, only 6 are selected to move onto clinical trials, and out of those 6, only 1 compound is approved by the Food and Drug Administration (FDA) and the product is introduced into the market. The low success rates associated with new drug development is what makes the demand for resources at different stages of the development pipeline highly variable and very difficult to predict. Even after a drug is launched into the market, success is not guaranteed as toxic side effects may erupt when the drug is introduced to a larger sample of diverse population. This unpredictable process together with the companys annual fixed cost of Research and Development creates a major financial risk. Nevertheless, pharmaceutical firms decide to undertake this risky process because of the opportunity to develop a blockbuster drug, a drug that generates $1 billion or more each year in sales revenue for the company, and has the capacity to meet unmet medical needs of the population. Pre-Discovery To Understand the Disease Before any potential new medicine can be discovered, scientists work to understand the causes as well as other underlying factors in relation to the disease to be treated as well as possible. Target Identification (Choose a molecule to target with a drug) Once they have enough understanding of the underlying cause of a disease, pharmaceutical researchers select a target for a potential new medicine. A target is generally a single molecule, such as a gene or protein, which is involved in a particular disease. Even at this early stage in drug discovery it is critical that researchers pick a target that is drugable, i.e., one that can potentially interact with and be affected by a drug molecule. Target Validation (Test the target and confirm its role in the disease) After choosing a potential target, scientists must show that it actually is involved in the disease and can be acted upon by a drug. Target validation is crucial to help scientists avoid research paths that look promising, but ultimately lead to dead ends. Researchers demonstrate that a particular target is relevant to the disease being studied through complicated experiments in both living cells and in animal models of disease. Various stages in Drug Development Process The drug development process is highly regulated and follows a number of well-defined steps and milestones. Discovery and screening stage Emerging tools in molecular biology, cell biology and combinatorial chemistry help researchers understand diseases and identify specific targets for new drugs. Once a specific target is identified, drug development starts with the screening of a large number of compounds to find the non-toxic compounds with the desired biological effects. Typically, thousands of chemical compounds are tested in test tubes or individual cells (tissue cultures). Drug companies maintain large libraries of newly synthesized or isolated compounds. Compound from these libraries are tested for biological activity. Preclinical testing Preclinical testing involves a series of short term and long term animal and laboratory tests to generate data on if a compound is safe and worthwhile to test on people. The aim of preclinical testing is to understand what happens when the drug is metabolized, as well as to generate information about the optimal dose for the clinical trials. Animal studies provide data on the absorption, distribution and excretion of the compound. The chemical properties of the discovered compounds are studied in significant detail at this step. Steps for synthesis and purification are developed at this time. These help identify any acute toxicity issues that may arise. It usually takes 3-4 years to gather data in support of Investigational New Drug Application (IND). This application notifies the Food and Drug Authority (FDA) of the drug sponsors intent to conduct clinical research on human. In parallel with the animal studies, the company has to conduct studies to determine how to manufacture repro ducible batches over time. Clinical trials The ultimate goal of clinical trials is to determine whether the drug works well enough in patients. The trials should address: whether the risk of toxic side effects outweighs the therapeutic benefit; which dose regimen provides the best response and the least number of side effects; if the drug is better than existing treatments or not. Clinical trials are divided in three phases Phase I (PI): In Phase I trials, the candidate drug is tested in people for the first time. These studies are usually conducted with about 20 to 100 healthy volunteers. The main goal of a Phase I trial is to discover if the drug is safe for humans. Researchers look at the pharmacokinetics of a drug: How is it absorbed? How is it metabolized and excreted from the body? They also study the pharmacologics of a drug: effects of the drug on the functioning of the human body. These closely monitored trials are designed to help researchers determine what the safe dosage range is and if it should move on to further development. Phase II (PII): The goal of this phase is to evaluate the effectiveness of the drug for a particular indication and how the drug behaves in people. These studies typically include 100-500 patients with a target disease or indication, divided into several subgroups. The subgroups are administered the drug in different dosages, by different routes, and on different schedules. Efforts are made to determine the common short term side effects and other risks associated with the drug when used on human beings. Phase III (PIII): The studies in this phase are conducted over a long term and on a large sample of 1000-1500 patient volunteers. The basic aim of this phase is to generate statistically significant data, about to evaluate the risks and benefits associated with the drug. The effectiveness and safety of the drug is carefully examined and dosing regiments duly noted which will lead to the FDA and the international regulatory agencies to approve the new drug. The results from these studies are used to develop the DRUG LABEL. The Drug Discovery process has many issues like Long Lead Times and Uncertainty that are plaguing the whole process and causing disturbances/tremors along the lines of New Product Development. Literature review A stochastic programming approach for clinical trial planning in new drug development Matthew Colvin, Christos T. Maravelias Due to changing circumstances in the managed-health-care environment, the profit margins of pharmaceutical companies and the productivity of their Research and Development (RD) pipelines have started to decline; effective patent lives have been shortened, and patents provide lower barriers to entry even while active. Therefore, it is imperative for pharmaceutical companies to manage their RD pipelines more effectively to reduce the cost of developing new drugs. This is a challenging task due to the highly stochastic nature of the RD process: if a drug fails a clinical trial, its development stops and all prior investment is lost; if it passes all trials, it enters the marketplace and profits are typically significantly larger than development costs. To effectively plan the clinical trials in the pharmaceutical RD pipeline, therefore, new systematic stochastic optimization methods are necessary.The paper presents a multi-stage stochastic programming formulation for the scheduling of c linical trials in the pharmaceutical research and development (RD) pipeline. The stages correspond to time periods, i.e. the planning horizon is divided into multiple periods. Scenarios are used to account for the endogenous uncertainty (a drug either passes or fails a clinical trial) in clinical trial outcomes. Given a portfolio of potential drugs and limited resources, the model determines which clinical trials (PI, PII, PIII) to be performed in each planning period and scenario in order to maximize the expected net present value of the RD pipeline. The proposed formulation can be used to address problems of medium size and serves as a basis for the development of advanced models for the management of the pharmaceutical RD pipeline. Knowledge networking to support medical new product development Kannan Mohan, Radhika Jain, Balasubramaniam Ramesh Pharmaceutical firms depend heavily upon their ability to rapidly develop and introduce new products into the market. Product development speed directly impacts their financial bottom-line as well as their ability to satisfy unmet medical needs of patients. However, development of new medical products is complex and time-consuming. It takes anywhere between 7 and 17 years and several millions to billions of dollars to launch new medical products. Some of the factors contributing to the length, cost, and uncertainty of this process are the stringent regulatory requirements of governmental entities like the FDA requiring the maintenance of design history for every medical product to show that the products were developed as per the approved plan and with extensive clinical trials, medical products are used to treat human beings whose well-being and safety are of utmost importance. Thus, failure of the product can have serious consequences, increasing possibilities for therapeutic interv ention brought about by newer technologies and enormous investments required in research and development, and testing. This paper addresses the issue of developing an approach to seamlessly integrate fragmented knowledge using knowledge networks. Semantic knowledge networks provide the ability to describe and follow the life of a physical or conceptual artefact. These have been used as effective solutions to support knowledge integration in knowledge intensive processes in multiple domains. Motivated by their effectiveness in supporting knowledge intensive processes, the paper proposes the creation and use of knowledge networks to facilitate integration of knowledge fragments that are generated and used in medical NPD. The development of a knowledge network should be guided by the unique characteristics of the medical NPD domain. The paper also provides the background on the process of medical NPD, along with unique issues in this area. New product development process and time-to-market in the generic pharmaceutical industry Janez Prasnikar, Tina Skerlj This article presents some important factors impacting on the lead-time of new products. In particular, we find a negative relationship between the incorporation of organizational tools and techniques, such as concurrent activity management and time-to-market. Further, there is an appropriate negative relationship between the integration of new product development departments in particular phases of the new product development process and the cycle-time of those phases. Appropriate capacity management and project management also contribute to a shorter lead-time of a new product. However, there are also some particularities of generic pharmaceutical companies. The retargeted products (where an existing product is launched in a new market) have longer time-to-market than completely new products. The generic pharmaceutical industry depends very much on local market conditions and it is often easier to launch new products in already existing markets than to launch existing products in n ew markets. Further, if the active pharmaceutical ingredient is sourced externally the time-to-market is shorter. The same is true of the external sourcing of the pharmaceutical formulation. Since generic companies often build their competencies in the market rather than on the technology used, strategic alliances and early supplier involvement in the new product development are important factors of their market success. Research objectives The Biopharmaceutical industry has many a process to be deeply understood and uniquely mapped, however, I would be looking at the following for the purpose of my project To understand the Drug Discovery Process and map it with New Product Development Understand how a pharmaceutical product is produced; identify all the stages from the Pre discovery phase to the Discovery phase and from the Pre clinical phase to the Clinical Phase and map it with New Product Development Identify the sources for reducing Uncertainty in the Drug Discovery Process One of the features that restrict the smooth functioning of the Drug Discovery process is uncertainty about the drug in trail. If the drug that is being tested fails the clinical trials phase, all the investment and effort towards drug development is lost, but if it passes all the trials, it enters the marketplace and benefits the company by providing profits that are typically significantly larger than the development costs. Identify the sources for reducing Lead Time in the Drug Discovery Process Drug development in the pharmaceutical sector is a lengthy process ranging anywhere from 7 to 17 years and costs the companies billions of dollars. Thus identification of sources for reduction in lead time and appropriate application of those steps would directly influence the costs and help in launching the product quicker than usual into the market. Research methodology Interaction with Biopharmaceutical Teams working on the Drug Discovery Process at the Biological Sciences and Biological Engineers (B.S.B.E) department at Indian Institute of Technology, Kanpur Secondary Research from Scientific Journals Case study approach in Business Press and Scientific Journals Chapters Introduction to the Drug Discovery Process Detailed explanation of the Drug Discovery Process Convergence with the New Product Development Literature Review Analysis of the related topic as described in Business Press and other Scientific journals. Research Objectives Research Methodology: An outline of the different approaches available for research Explanation of the different approaches and their outcomes with respect to the project Results and Discussions of the case Management Insights Relation of the Drug Discovery Process with Management concepts Conclusions and Future Research

The Way of Life Frank Represents Compared to Ritas :: Educating Rita Relationships Willy Russell Essays

The Way of Life Frank Represents Compared to Rita's Rita is seeking a better way of living her life and Frank represents the life style she wishes to live. She understands she is of a working class background, and wants to be more cultured. Rita wants more meaning to her life. She wants to know the right things to say and what wine to buy, the type of attributes she admires in Frank, and people similar to him. She does not want to be just a housewife and mother, the two exact things Denny her husband wants her to be in order that she fits in with the rest of their society. He tries to control her and prevent her from learning, he burns her books and constantly nags at her to come off the pill so that she can have a child and settle down, just like everyone else they know. Denny's ideas are evident when he says; 'There's a time for education. An' it's not when y' twenty-six an' married.' Basically she has to make a choice between her education or her family, because as she changes to become a more sophisticated and educated woman, she widens the gap between her and the people in her old life, them being ignorant and uncultured. First of all, it is noticeable that because of Rita's working class background, one particular quality of hers is her lack of self-consciousness, which prevents her from being prudish. This is revealed in Act 1 Scene 1 when Rita comments on Frank's picture on the wall; "Look at those tits," she says bluntly, within minutes of meeting her new tutor. Frank, having had a middle class upbringing is embarrassed by her frank observation. He has the good judgment to realise that on first being acquainted with someone this kind of comment is not really appropriate, whereas Rita is almost like a child, not having the expected amount of subtlety and the sense to be discreet. These qualities are what hinders Rita from becoming more like Frank. However, it is this type of behaviour which draws Frank to Rita, he finds her new, unique, and original because she does not follow the unspoken rule of how to behave on meeting a stranger. In Act 1 Scene 1 he describes her as; "The first breath of air that's been in this room for years." He views his life as dull and stale, Rita stepping in begins to make his life seem more interesting, she livens it up. On becoming more educated, Rita also has to leave behind a positive aspect of her old life, a close-knit community with close links.

Clinton Administration Policy Toward The Caribbean Country Of Haiti :: William Jefferson Clinton Essays

Clinton Administration Policy Toward the Caribbean Country of Haiti The topic for this paper is the United States policy towards the Caribbean country of Haiti during the Clinton administration. The subjects which will be discussed are the issues of: Refugees, Foreign Aide as well as human rights the United States involvement in Haiti issues of national interests. What will also be examined is what the Clinton administration trying to achieve concerning Haiti. What the United Nations and the U.S. roles were, and what the public thought was concerning these issues. Also why the United States was involved with the internal dispute of a third world country where the national interest was not clearly defined. The issue of why was it or was not so important for the United States to send troops to Haiti will also be discussed. The problem in Haiti was the pro democratic elected president Aristide was exile from Haiti during a military coup. Several issues arose out of Haiti after the exile of Aristide. Issues of: human rights there were reports that the new regime brought back "death squads" killing people who opposed the new leaders. One of the main targets of the Clinton policy is a group called the Front for the Advancement and Progress of Haiti of FRAPH. The administration has targeted this group for their continued backing and support of General Cedras, for their human rights violations. Issues of , refugee's illegally trying to enter the United States creating an economic burden on much of south Florida. All of these issues arose during president Bush's term in office. The Bush administration was to turn back the refugee's. The Bush administration saw no vital national interest in concerning it self with the internal problems of Haiti ,because there were so many problems at home in the United States, other than to turn the refugee's away from south Florida. When president Clinton took over the office of the presidency he would become very indecisive and weak on the issue of Haiti. President Clinton began badly on Haiti. With his continual indecision and lack of any real back bone to the policies which were decided upon. "First, he gave charge of his policy to Bush administration holdovers who over the previous year had made clear their intent to construct in Haiti a version of democracy that left the president in exile but with an Aristide - appointed prime minister and cabinet. This tortured scenario was doomed to failure because over two thirds of the Haitian people equated democratic government with the return of Aristide and no arrangement that excluded his presence could

The Founding Father of Jazz: Louis Armstrong

Foundations of the Founding Father of Jazz: Louis Armstrong Being heard in movies, the radio, television, and even elevators, jazz music has made its mark in just about every single location of the world. As popular as jazz is around the world, its original roots and foundations in the African-American culture are often forgotten. One of the most influential jazz musicians, Louis Armstrong, also known as Satchmo or Pops, is considered to be among the founding fathers of jazz music. His career launched in the early 1900s, where his legacy would form early to create a sound foundation for early jazz music that was quite exceptional.Louis Armstrong was such an essential part of the jazz age during the 1920’s that his music created a firm foundation, paving the way for Jazz musicians everywhere. His influential singing, along with his great dexterity, intricate lyrics, and profound melodies make it easy for him to claim his title as â€Å"The Founding Father of Jazz. † Taki ng his first breath in the world on August 4, 1901, Louis Armstrong was born to William and Mary â€Å"Mayanne† Albert Armstrong in the â€Å"Battlefield† of New, Orleans, Louisiana – one of the poorest areas of town (Old 15).Shortly after his birth, he was abandoned by his father, a factory worker, to be left with his mother, struggling to make ends meet (Old 16). Armstrong’s childhood was rather tough considering the fact that he had been abandoned by his father. Also, as times worsened, he was abandoned by his mother as she turned to prostitution to earn additional cash. He and his younger sister, Beatrice Armstrong Collins, were often left in the care of his maternal grandmother, Josephine Armstrong and their Uncle Isaac (Old 16).At age five, he moved back to live with his mother and relatives and very rarely saw his father. Armstrong had much respect for his mother; he wrote, â€Å"She held up her head at all times†¦What she didn’t have, she did without. † (Old 22) As a youngster, Armstrong was often seen singing in the streets with his friends to earn money. He was a very smart boy, but he often made the wrong decisions. He skipped from kindergarten into the second grade and grew up in a rough area where he would learn to shoot dice for pennies and play blackjack (Old 23).He attended the Fisk School for Boys in 1906 where he was first exposed to a large variety of music and brought in extra money as a paperboy, selling food to restaurants, and hauling coal to Storyville. However, he was not able to help his mother from turning to prostitution. Often times, young Armstrong explored local dance halls where he would soak in various aspects to the music business, including the music itself, performances, and dancing. The infamous Storyville is where Armstrong often listened to bands and musicians which included Joe â€Å"King† Oliver and other famous vocalists (Old 36).A fast forward to the year of 1912 b rings us to the beginnings of Armstrong’s involvement in instrumental music. In this very year, he dropped out of the Fisk School for boys and began to make a living by singing on the streets of New Orleans with a quartet group. During the time Armstrong performed with the quartet, Joe â€Å"King† Oliver taught him how to play the cornet. Because Armstrong did not have much family support, he was often left to his lonesome. However, a very kind Lithuanian-Jewish family, the Karnofskys, who gave him odd jobs from time to time took him in and treated him as their own.Eventually, the Karnofskys loaned him money for his first very own cornet, which would give him one of the necessary tools needed to be a successful musician – an instrument (Morgenstern 100). Although Armstrong’s positive image and career outlook began to develop in a great way that soon took a change in 1914 when he was sent to the New Orleans Home for Colored Waifs, a delinquency home (Old 2 7). During that time, he was most known for his arrest due to firing his stepfather’s pistol into the air at a New Year’s Eve celebration.While at home, he was appointed to be the band leader for The Home band as they played all around New Orleans at the age of 13 years old. His musical career became more popular as he gained attention from the public eye for his evident cornet playing skills. At the age of 14, Armstrong was released from the home, returned to live with his father and stepmother, and soon to live with his mother again. Moving back with his mother put him in an environment that led him back to performing on the streets and being tempted by the red-light district lifestyle.Shortly after moving in with his mother, he got his first dance hall job (Henry Ponce’s) where he hauled coal by day and played cornet at night, making his skills well-known once again. Armstrong frequently performed as a cornet player which eventually helped him develop his own style and a more serious attitude toward music. He played in the city’s brass band parades, riverboats and steamboats, and took notes from other musicians with every change he got. Perfecting his craft was something that was very important to him.Some influential musicians that affected Armstrong’s career included Buck Johnson, Buddy Petit, Kid Ory, and Joe â€Å"King† Oliver. King soon became a mentor and somewhat of a father figure for the young musician who seemed to have no relevant family relationships or strong ties. His participation in playing on steamboats around New Orleans led him to travel with the popular band, Fate Marable. As he and the well-regarded band toured up and down the Mississippi River, much experience was gained by working with written musical pieces and arrangements.In 1917, Armstrong began playing with Kid Ory’s band until 1919 when Joe Oliver decided to move north and resign his position in the band. 1919 marks the year Armst rong became an official band member and replaced the â€Å"King. † Also, in that year, he became the second trumpeter for the Tuxedo Brass Band in New Orleans. In between his time playing with Kid Ory, Armstrong married Daisy Parker (Gretna, Louisiana) on March 19, 1918 (Old 39). Around that time Louis’ cousin, whose mother, Flora, died shortly after giving birth, had been taken in by the newlyweds.The three-year-old boy, Clarence Armstrong, who was mentally disabled, became one of Louis’ main responsibilities. Although both Daisy and Louis were parenting Clarence, the marriage did not last very long. They quickly separated and filed for divorce. However, Parker died shortly after the divorce. As Armstrong’s career began to develop even more, some adjustment had to be made to perfect his craft even more. In 1921, Louis Armstrong learned how to efficiently read music. His improvements led to great advancements as he joined Oliver’s Creole Jazz Band in Chicago in 1922.While working with the band, he took interest in Lillian (Lil) Hardin, the pianist, and they soon got married. His marriage with Lil lasted much longer than his first and they accomplished great things together. Although Louis Armstrong is renowned for his incredible jazz records, it is not widely known that many of his greatest hits were written and arranged by his wife at the time. She played the piano, composed, and arranged music for most of the important bands from New Orleans at the time.Lil Armstrong was a major contributor to her husband’s success as she composed hundreds of records and created musical successes (Kallen 32). In 1923, as paychecks continued to roll in, Armstrong’s career began to take a turn for the better. His lucrative career provided the proper finances for his lavish lifestyle maintained in Chicago, where he met Hoagy Carmichael. A mutual friend, Bix Beiderbecke, introduced the two to each other and they later collaborated on several projects. Jazz music began to circulate and spread through speakeasies, ballrooms, and dancehalls of Chicago (Kallen 30).It was very important that Armstrong would move to Chicago during the 1920s in order to keep up with the times. African-Americans moved away from the South to industrial states in the North; this was known as the Great Migration (Kallen 28). The city nicknamed â€Å"Chi-Town† became the major hub for gangsters, illegal nightclubs (speakeasies), and illegal liquor trade. The speakeasies were a major launching place for black musicians because they provided a place for the musicians to perform, earn lucrative paychecks, and led to a golden age of innovation (Kallen 28).Although Armstrong thoroughly enjoyed working with Oliver in Chicago, his wife suggested that he seek more advisement in order to develop and expand his newer style which was quite different from Oliver’s. Listening to his wife, Armstrong left Oliver’s band, and began to play in Fletcher Henderson’s band in Harlem, New York, 1924. The Henderson band, being highly respected, played in only the best venues and often for white-only crowds. While in Henderson’s band, he adapted to their controlled sound and style of play and incorporated storytelling and singing into his acts.Armstrong also made many side recordings which included the likes of Bessie Smith, Ma Rainey, and Alberta Hunter. Many of these collaborations were arranged by an old friend back in New Orleans, Clarence Williams. Although he made quite a name for himself in the big city, his stay in New York did not last long; he eased on down back to Chicago in 1925 in hope of boosting his career, increase income, and gain more publicity. Introduced as â€Å"the World’s Greatest Trumpet Player,† Armstrong began to play with the Lil Hardin Armstrong Band but eventually began to record under his own name instead of joint projects with his wife.He recorded under Okeh a nd worked with his own groups, the Hot Five and the Hot Seven. Popular hits during this time include â€Å"Potato Head Blues,† Muggles,† and â€Å"West End Blues. † Several hits, including â€Å"Muggles† had references that indicated Armstrong’s long-time fondness of recreational plant use with marijuana. After working with the groups Hot Five and Hot Seven, Armstrong went into great ventures forming another band – Louis Armstrong & the Stompers. The band toured with the classic musical, Hot Chocolate, and had notable performances.He also made cameo appearances as a vocalist, often taking the spotlight with his rendition of â€Å"Ain’t Misbehavin. † Armstrong’s version of the song was quick to gain popularity and became his biggest selling record of all time. Armstrong eventually moved to Los Angeles in 1930 and played in the Cotton Club with elaborate floor shows and celebrity guests. At the Cotton Club, he had notable s uccess with his vocal recordings and even renditions of other famous songs. His recordings took a chance of course with the introduction of the RCA ribbon microphone in 1931.Intrinsic music style change showcased Armstrong’s unique vocal style and gave him a more innovative approach to singing. It would not be long before Armstrong would make appearances in film. In fact, in 1931, he appeared in his first movie, Ex-Flame. However, shortly thereafter, he was convicted for possession of marijuana, induced conflict upon himself with the mob, moved back to New Orleans, and eventually fled to Europe. As a comeback attempt, which was successful, Armstrong and his band worked with Joe Glaser to record with the Mills Brothers, Louis Jordan, Tommy Dorsey, and even Ella Fitzgerald.He later appeared in the film, â€Å"Pennies from Heaven† with Bing Crosby in 1936 and in 1937, he became the first black to host a sponsored, national radio broadcast. Louis Armstrong’s career began to rise again; however, his marriage did not experience the same thing. After having a variety of issues with his wife, Lil, they decided to divorce in 1938 and he began his third marriage with a woman named Alpha and his image to the public became a major concern. In addition to Armstrong’s marijuana usage, he loved to eat food and write in his journal.Several journal entries range from implicit to explicit notes which include several accounts regarding his sex life, music, childhood memories, and even a few jokes. He also went into great detail to describe food – the taste of it, the smell of it, the textures, and the way it made him feel on the inside. Food truly made him a soulful man with a smile on his face. However, his love for food became a problem when it came to health concerns. Armstrong was at major risk of high blood pressure, heart disease, diabetes, and even obesity.It became his primary goal to control his weight. Often times, he would be seen ta king laxatives and offering them to his band mates. It was very important to him to maintain a certain image that he would be perceived as a fit man; being in many films inspired him to do so. Some who worked with him also recalled times he would purge him in order to control weight. Armstrong’s life as not only an entertainer, but a leading personality, made him a great man adored by Americans in the 1900s. He gave even the greatest performers something to learn from.His influential jazz styles along with his loving personality gave him the career of a lifetime and truly a great experience. Louis Armstrong and his legacy as a Jazz musician continue on. â€Å"The Founding Father of Jazz† left a mark in music history that cannot be erased. Works Cited Armstrong, Louis. Satchmo: My Life in New Orleans. New York, NY: Da Capo, 1986. Print. Bergreen, Laurence. Louis Armstrong: An Extravagant Life. New York: Broadway, 1997. Print. â€Å"Jazz . Jazz Greats . Louis Armstrong | PBS KIDS GO! †Ã‚  Jazz . Jazz Greats . Louis Armstrong | PBS KIDS GO!PBS Kids, n. d. Web. Nov. 2012. . Kallen, Stuart A. The History of Jazz. San Diego: Lucent, 2003. Print. â€Å"Louis Armstrong. †Ã‚  Musician (Trumpet) @ All About Jazz. N. p. , n. d. Web. Nov. 2012. . â€Å"Louis Armstrong. †Ã‚  Musician (Trumpet) @ All About Jazz. NPR, n. d. Web. Nov. 2012. . Old, Wendie C. Louis Armstrong: King of Jazz. Springfield, NJ: Enslow, 1998. Print.